The National Tuberculosis Programme (NTP) is fully integrated within the general primary health care system of Government of Nepal. National Tuberculosis Centre (NTC) is the focal point of the NTP. It is responsible for formulating programme policies, strategy and planning.

Central laboratory at the NTC is the focal point for the NTP laboratory network, which is responsible for policy and guideline development, training, quality control and supervision. Technical support, monitoring and evaluation, training, supervision, logistics, health education, communication, and research are key functions of NTC.

Furthermore, quantification and procurement and supply of anti-tuberculosis drugs are key responsibilities of the NTC. The NTC is procuring both first and second line anti TB drugs for the TB patients from Global Drug Facility (GDF). Drugs are distributed through the system of Logistics Management Division of the Department of Health Services. NTC has also established Programme Management Unit (PMU) at the central level for overall management of the Global Fund grants and provide technical inputs to formulate policies, program, implementation, monitoring and evaluation for the programme.

At the Regional level, NTP activities are planned and carried out in coordination and cooperation with the Regional Health Directorate. The Regional Tuberculosis Centre (RTC) in Pokhara provides technical support to TB control activities in the Western Region in coordination with National Tuberculosis Center. There is full time permanent Regional TB Leprosy Officers (RTLO) appointed in each region. Regional levels are responsible for programme implementation within the regions. In addition, the regional office is responsible for training, monitoring & evaluation and supervision of programme activities. Regional office also provides logistical support, supply of TB drugs and other requirement through Regional Logistic Management Division.